Assay Detail
Binding
CHEMBL2412780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.79 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 10.00 |
| CHEMBL1229592 | — | — | 1 | 8.49 |
| CHEMBL2408828 | — | — | 1 | 6.89 |
| CHEMBL2408829 | — | — | 1 | 6.62 |
| CHEMBL2408830 | — | — | 1 | 6.46 |
| CHEMBL2408825 | — | — | 1 | 5.96 |
| CHEMBL2408823 | — | — | 1 | 5.64 |
| CHEMBL2408824 | — | — | 1 | 5.53 |
| CHEMBL2408826 | — | — | 1 | 5.50 |
| CHEMBL2408827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1229592 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2408828 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2408829 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2408830 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2408825 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2408823 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL2408824 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL2408826 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL2408827 | — | IC50 | > | 10000.0 | nM | - |