Assay Detail
Functional
CHEMBL2412943
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Cytotoxicity against human HCT116 cells assessed as growth inhibition by measuring cellular ATP level after 72 hrs by cell-titer glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.48 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.86 |
| CHEMBL2407720 | — | — | 1 | 5.71 |
| CHEMBL2407717 | — | — | 1 | 5.66 |
| CHEMBL2407737 | — | — | 1 | 5.44 |
| CHEMBL2407735 | — | — | 1 | 4.78 |
| CHEMBL2407736 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2407720 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL2407717 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL2407737 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL2407735 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL2407736 | — | IC50 | = | 18200.0 | nM | 4.74 |