Assay Detail
Binding
CHEMBL2415113
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Inhibition of iNOS-mediated NO production in IL-1beta/IFNgamma-stimulated rat RINmF cells by Griess reaction
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nitric oxide synthase, inducible (CHEMBL3051) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Investigations on synthesis and structure elucidation of novel [1,2,4]triazolo[1,2-a]pyridazine-1-thiones and their inhibitory activity against inducible nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.48 | 5.01 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2414836 | — | — | 1 | 5.01 |
| CHEMBL2414846 | — | — | 1 | 4.88 |
| CHEMBL2414845 | — | — | 1 | 4.79 |
| CHEMBL2414844 | — | — | 1 | 4.62 |
| CHEMBL2414855 | — | — | 1 | 4.52 |
| CHEMBL2414851 | — | — | 1 | 4.40 |
| CHEMBL2414840 | — | — | 1 | 4.27 |
| CHEMBL2414843 | — | — | 1 | 4.24 |
| CHEMBL2414838 | — | — | 1 | 4.22 |
| CHEMBL2414841 | — | — | 1 | 4.20 |
| CHEMBL2414847 | — | — | 1 | 4.16 |
| CHEMBL2414854 | — | — | 1 | - |
| CHEMBL2414853 | — | — | 1 | - |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | - |
| CHEMBL2414852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2414836 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL2414846 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2414845 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL2414844 | — | IC50 | = | 24160.0 | nM | 4.62 |
| CHEMBL2414855 | — | IC50 | = | 29890.0 | nM | 4.52 |
| CHEMBL2414851 | — | IC50 | = | 40190.0 | nM | 4.40 |
| CHEMBL2414840 | — | IC50 | = | 53230.0 | nM | 4.27 |
| CHEMBL2414843 | — | IC50 | = | 57590.0 | nM | 4.24 |
| CHEMBL2414838 | — | IC50 | = | 60260.0 | nM | 4.22 |
| CHEMBL2414841 | — | IC50 | = | 62970.0 | nM | 4.20 |
| CHEMBL2414847 | — | IC50 | = | 70030.0 | nM | 4.16 |
| CHEMBL2414854 | — | Inhibition | - | % | - | |
| CHEMBL2414853 | — | Inhibition | - | % | - | |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 132010.0 | nM | - |
| CHEMBL2414852 | — | IC50 | = | 101080.0 | nM | - |