Assay Detail
Binding
CHEMBL2415223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to His-tagged STAT3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as inhibition of protein dimerization by fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2367507 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2367507 | — | IC50 | = | 300.0 | nM | 6.52 |