Assay Detail
Binding
CHEMBL2415373
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 17beta-HSD5 expressed in HEK293 cells using androstenedione as substrate assessed as testosterone synthesis after 4 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.05 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2413849 | — | — | 1 | 9.47 |
| CHEMBL2413850 | — | — | 1 | 8.68 |
| CHEMBL2413860 | — | — | 1 | 8.35 |
| CHEMBL2413851 | — | — | 1 | 7.92 |
| CHEMBL2413852 | — | — | 1 | 7.89 |
| CHEMBL2413853 | — | — | 1 | 7.48 |
| CHEMBL2413863 | — | — | 1 | 7.43 |
| CHEMBL2413855 | — | — | 1 | 6.85 |
| CHEMBL2413861 | — | — | 1 | 6.80 |
| CHEMBL2413857 | — | — | 1 | 6.64 |
| CHEMBL2413859 | — | — | 1 | 6.11 |
| CHEMBL2413864 | — | — | 1 | 6.10 |
| CHEMBL2413856 | — | — | 1 | 5.96 |
| CHEMBL2413854 | — | — | 1 | 5.92 |
| CHEMBL2413858 | — | — | 1 | 5.68 |
| CHEMBL2413862 | — | — | 1 | 5.55 |
| CHEMBL2413848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2413849 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL2413850 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2413860 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2413851 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2413852 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2413853 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2413863 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2413855 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2413861 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2413857 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2413859 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2413864 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2413856 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2413854 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2413858 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2413862 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2413848 | — | IC50 | > | 10000.0 | nM | - |