Assay Detail
Binding
CHEMBL2415523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-RX821002 from alpha2 adrenoreceptor in rat brain cortical membranes after 45 mins by liquid scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.96 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.00 |
| CHEMBL2414357 | — | — | 1 | 6.21 |
| CHEMBL2414358 | — | — | 1 | 5.85 |
| CHEMBL2414356 | — | — | 1 | 5.80 |
| CHEMBL2414354 | — | — | 1 | 5.68 |
| CHEMBL597601 | — | — | 1 | 5.60 |
| CHEMBL2414355 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2414357 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL2414358 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2414356 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL2414354 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL597601 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2414355 | — | Ki | = | 2800.0 | nM | 5.55 |