Assay Detail
Binding
CHEMBL2417040
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Competitive binding affinity to human adenosine A2A receptor expressed in HEK293 cells after 60 mins by fluorescence polarization assay in presence of MRS5346
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorescent ligands for adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.11 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | — | 1 | 8.89 |
| CHEMBL17127 | SCH-58261 | — | 1 | 8.72 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | — | 1 | 8.43 |
| CHEMBL136689 | — | — | 1 | 7.96 |
| CHEMBL464859 | NECA | — | 1 | 7.67 |
| CHEMBL2391907 | — | — | 1 | 7.56 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 6.20 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.09 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.69 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 5.61 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113142 | ZM-241385 | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL17127 | SCH-58261 | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL273094 | XANTHINE AMINE CONGENER | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL136689 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL464859 | NECA | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL2391907 | — | Ki | = | 27.3 | nM | 7.56 |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 814.0 | nM | 6.09 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL113 | CAFFEINE | Ki | = | 2480.0 | nM | 5.61 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 3720.0 | nM | 5.43 |