Assay Detail
Binding
CHEMBL2422528
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Inhibition of PDE10A (unknown origin)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.88 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | 2.0 | 1 | 8.59 |
| CHEMBL2419369 | — | — | 1 | 7.92 |
| CHEMBL2419368 | — | — | 1 | 7.89 |
| CHEMBL2419555 | — | — | 1 | 7.80 |
| CHEMBL2419366 | — | — | 1 | 7.62 |
| CHEMBL2419561 | — | — | 1 | 7.51 |
| CHEMBL1086110 | — | — | 1 | 7.50 |
| CHEMBL2419548 | — | — | 1 | 7.21 |
| CHEMBL219445 | — | — | 1 | 7.19 |
| CHEMBL2419364 | — | — | 1 | 7.06 |
| CHEMBL2419365 | — | — | 1 | 7.06 |
| CHEMBL2419554 | — | — | 1 | 7.03 |
| CHEMBL2419367 | — | — | 1 | 6.96 |
| CHEMBL2419553 | — | — | 1 | 6.89 |
| CHEMBL2419552 | — | — | 1 | 6.85 |
| CHEMBL19224 | PAPAVERINE | 3.0 | 1 | 6.68 |
| CHEMBL2419551 | — | — | 1 | 6.62 |
| CHEMBL2419564 | — | — | 1 | 6.60 |
| CHEMBL2419550 | — | — | 1 | 6.40 |
| CHEMBL2419560 | — | — | 1 | 6.34 |
| CHEMBL2419557 | — | — | 1 | 6.18 |
| CHEMBL2419556 | — | — | 1 | 6.18 |
| CHEMBL2419563 | — | — | 1 | 6.12 |
| CHEMBL2419547 | — | — | 1 | 6.04 |
| CHEMBL2419549 | — | — | 1 | 6.02 |
| CHEMBL2419371 | — | — | 1 | 5.80 |
| CHEMBL2419370 | — | — | 1 | 5.80 |
| CHEMBL2419559 | — | — | 1 | - |
| CHEMBL2419558 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562318 | MARDEPODECT | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2419369 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2419368 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2419555 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2419366 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2419561 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1086110 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2419548 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL219445 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2419364 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2419365 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2419554 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2419367 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2419553 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2419552 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL19224 | PAPAVERINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2419551 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2419564 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2419550 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2419560 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2419557 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2419556 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2419563 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2419547 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2419549 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL2419371 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2419370 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2419559 | — | IC50 | - | — | - | |
| CHEMBL2419558 | — | IC50 | - | — | - |