Compound Detail
CHEMBL2419368
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Basic Information
| ChEMBL ID | CHEMBL2419368 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FZMHOVFBMKBANK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
435.5
MW (Da)
4.88
ALogP
5
HBA
1
HBD
84.0
PSA (Ų)
0.41
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 13.0 | nM | 7.89 | Inhibition of PDE10A (unknown origin) | 23978358 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23978358 | 10.1016/j.bmc.2013.07.030 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 2 |
Data from ChEMBL 36 via Core Engine