Assay Detail
Binding
CHEMBL2422547
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Displacement of [3H]prazosin from human alpha-1B adrenoreceptor expressed in CHO cells after 30 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.08 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215421 | — | — | 1 | 8.24 |
| CHEMBL217469 | — | — | 1 | 7.80 |
| CHEMBL2419771 | — | — | 1 | 7.66 |
| CHEMBL2419769 | — | — | 1 | 7.54 |
| CHEMBL3216590 | — | — | 1 | 7.45 |
| CHEMBL2419770 | — | — | 1 | 6.90 |
| CHEMBL2419772 | — | — | 1 | 6.79 |
| CHEMBL3217244 | — | — | 1 | 6.43 |
| CHEMBL2419765 | — | — | 1 | 6.31 |
| CHEMBL2419766 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215421 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL217469 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL2419771 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL2419769 | — | Ki | = | 28.84 | nM | 7.54 |
| CHEMBL3216590 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL2419770 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL2419772 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL3217244 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL2419765 | — | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL2419766 | — | Ki | = | 1905.46 | nM | 5.72 |