Assay Detail
Binding
CHEMBL2422669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selectivity data: assessment, predictions, concordance, and implications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.63 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574738 | AST-487 | 1.0 | 1 | 8.30 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 7.60 |
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574738 | AST-487 | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL482967 | CYC-116 | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | = | 100.0 | nM | 7.00 |