Assay Detail
Functional
CHEMBL2422986
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Inhibition of protein synthesis in Escherichia coli S30 extracts after 90 mins by coupled transcription/translation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.48 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | 4.0 | 1 | 7.82 |
| CHEMBL2417987 | — | — | 1 | 6.57 |
| CHEMBL2418138 | — | — | 1 | 6.37 |
| CHEMBL2417984 | — | — | 1 | 6.01 |
| CHEMBL2417982 | — | — | 1 | 6.00 |
| CHEMBL2417983 | — | — | 1 | 5.83 |
| CHEMBL2417988 | — | — | 1 | 5.21 |
| CHEMBL130 | CHLORAMPHENICOL | 4.0 | 1 | 5.19 |
| CHEMBL2417981 | — | — | 1 | 4.83 |
| CHEMBL2417980 | — | — | 1 | 4.74 |
| CHEMBL1753 | CLINDAMYCIN | 4.0 | 1 | 4.74 |
| CHEMBL2417985 | — | — | 1 | 4.59 |
| CHEMBL2417986 | — | — | 1 | 4.48 |
| CHEMBL2417989 | — | — | 1 | 4.31 |
| CHEMBL2418137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1747 | TOBRAMYCIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2417987 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2418138 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2417984 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2417982 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2417983 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL2417988 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL130 | CHLORAMPHENICOL | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2417981 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL2417980 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL1753 | CLINDAMYCIN | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL2417985 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL2417986 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL2417989 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL2418137 | — | IC50 | > | 100000.0 | nM | - |