Assay Detail
Binding
CHEMBL2423360
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Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.85 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419538 | — | — | 1 | 8.29 |
| CHEMBL2419539 | — | — | 1 | 8.16 |
| CHEMBL2419540 | — | — | 1 | 8.07 |
| CHEMBL2419542 | — | — | 1 | 8.04 |
| CHEMBL2419537 | — | — | 1 | 7.92 |
| CHEMBL2419544 | — | — | 1 | 7.68 |
| CHEMBL2419541 | — | — | 1 | 7.58 |
| CHEMBL2419543 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419538 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2419539 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2419540 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2419542 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL2419537 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2419544 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2419541 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2419543 | — | IC50 | = | 85.0 | nM | 7.07 |