Assay Detail
Binding
CHEMBL2423366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPDPE from rat MOR expressed in HN9.10 cell membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.57 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419544 | — | — | 1 | 9.54 |
| CHEMBL2419543 | — | — | 1 | 7.82 |
| CHEMBL2419541 | — | — | 1 | 7.64 |
| CHEMBL2419542 | — | — | 1 | 7.48 |
| CHEMBL2419539 | — | — | 1 | 7.20 |
| CHEMBL2419540 | — | — | 1 | 7.12 |
| CHEMBL2419538 | — | — | 1 | 6.96 |
| CHEMBL2419537 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419544 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2419543 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2419541 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2419542 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2419539 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL2419540 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL2419538 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2419537 | — | Ki | = | 150.0 | nM | 6.82 |