Assay Detail
Binding
CHEMBL2423469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC10 enzyme using tetrapeptide Ac-ArgThr-Lys(Ac)Lys(Ac)-AMC as substrate after 15 to 30 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as β²- epi-Azumamide E and β³-epi-Azumamide E.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.85 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257972 | AZUMAMIDE C | — | 1 | 8.00 |
| CHEMBL402363 | AZUMAMIDE E | — | 1 | 7.70 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257972 | AZUMAMIDE C | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL402363 | AZUMAMIDE E | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL343448 | ROMIDEPSIN | Ki | - | — | - | |
| CHEMBL98 | VORINOSTAT | Ki | - | — | - |