Assay Detail
Functional
CHEMBL2423555
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Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modulation of human neutrophils' oxidative burst by flavonoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.74 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243677 | — | — | 1 | 5.31 |
| CHEMBL243664 | ACACETIN | — | 1 | 5.16 |
| CHEMBL214321 | CHRYSOERIOL | — | 1 | 5.15 |
| CHEMBL28 | APIGENIN | — | 1 | 5.11 |
| CHEMBL222556 | — | — | 1 | 5.09 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.02 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.02 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.95 |
| CHEMBL301624 | — | — | 1 | 4.83 |
| CHEMBL90568 | DIOSMETIN | — | 1 | 4.82 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 4.81 |
| CHEMBL307893 | — | — | 1 | 4.81 |
| CHEMBL457821 | — | — | 1 | 4.80 |
| CHEMBL76426 | — | — | 1 | 4.80 |
| CHEMBL294878 | — | — | 1 | 4.57 |
| CHEMBL32571 | — | — | 1 | 4.51 |
| CHEMBL502242 | — | — | 1 | 4.50 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 4.48 |
| CHEMBL253786 | — | — | 1 | 4.46 |
| CHEMBL147552 | — | — | 1 | 4.33 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 4.24 |
| CHEMBL484662 | — | — | 1 | 4.17 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243677 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL243664 | ACACETIN | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL214321 | CHRYSOERIOL | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL28 | APIGENIN | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL222556 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL117 | CHRYSIN | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL50 | QUERCETIN | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL301624 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL90568 | DIOSMETIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL307893 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL457821 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL76426 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL294878 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL32571 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL502242 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL253786 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL147552 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL275638 | FLAVONE | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL484662 | — | IC50 | = | 67800.0 | nM | 4.17 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | IC50 | = | 96000.0 | nM | 4.02 |