Assay Detail
Functional
CHEMBL2423976
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Chemosensitization of human HCT116 cells expressing p53 after 5 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.79 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419257 | — | — | 1 | 5.26 |
| CHEMBL2205662 | — | — | 1 | 5.21 |
| CHEMBL2419260 | — | — | 1 | 5.12 |
| CHEMBL2419254 | — | — | 1 | 4.88 |
| CHEMBL2419258 | — | — | 1 | 4.55 |
| CHEMBL2419251 | — | — | 1 | 4.26 |
| CHEMBL435951 | MITOZOLOMIDE | 2.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419257 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2205662 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2419260 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2419254 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2419258 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2419251 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL435951 | MITOZOLOMIDE | IC50 | = | 60000.0 | nM | 4.22 |