Assay Detail
Functional
CHEMBL2423980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Chemosensitization of human A2058 cells after 5 days by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2058 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.10 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419260 | — | — | 1 | 5.60 |
| CHEMBL2419258 | — | — | 1 | 5.26 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | 4.45 |
| CHEMBL2419254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419260 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2419258 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL2419254 | — | IC50 | > | 100000.0 | nM | - |