Assay Detail
Functional
CHEMBL2424044
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Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Additional cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes violatinctus and biogenetic considerations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.25 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340160 | ASCIDIDEMIN | — | 1 | 6.60 |
| CHEMBL2419311 | — | — | 1 | 5.37 |
| CHEMBL124083 | — | — | 1 | 4.84 |
| CHEMBL127939 | — | — | 1 | 4.72 |
| CHEMBL2419310 | — | — | 1 | 4.72 |
| CHEMBL2419312 | — | — | 1 | - |
| CHEMBL2419313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340160 | ASCIDIDEMIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2419311 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL124083 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL127939 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2419310 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2419312 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2419313 | — | IC50 | > | 10000.0 | nM | - |