Assay Detail
Binding
CHEMBL2424089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin (unknown origin) assessed as fibrin clot formation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.85 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419745 | — | — | 1 | 7.80 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 6.96 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419745 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL266349 | MELAGATRAN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 1580.0 | nM | 5.80 |