Assay Detail
Binding
CHEMBL2424091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of plasma clot-bound thrombin (unknown origin) using S2238 as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.47 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419745 | — | — | 1 | 8.30 |
| CHEMBL266349 | MELAGATRAN | 4.0 | 1 | 7.07 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419745 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL266349 | MELAGATRAN | IC50 | = | 85.2 | nM | 7.07 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 92.4 | nM | 7.03 |