Assay Detail
Binding
CHEMBL2424299
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Inhibition of HDAC10 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.77 | 6.57 |
| Kd | 1 | 4.91 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227118 | — | — | 1 | 6.57 |
| CHEMBL178456 | — | — | 1 | 4.97 |
| CHEMBL94394 | BUFEXAMAC | 4.0 | 1 | 4.91 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227118 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL178456 | — | IC50 | = | 10650.0 | nM | 4.97 |
| CHEMBL94394 | BUFEXAMAC | Kd | = | 12300.0 | nM | 4.91 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | > | 10000.0 | nM | - |