Assay Detail
Binding
CHEMBL2427120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta aggregation (unknown origin) after 4 hrs by thioflavin S assay in presence of Zn2+
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.94 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425960 | — | — | 1 | 5.26 |
| CHEMBL2425961 | — | — | 1 | 5.17 |
| CHEMBL2425959 | — | — | 1 | 5.13 |
| CHEMBL858 | EDETIC ACID | 3.0 | 1 | 5.11 |
| CHEMBL2425958 | — | — | 1 | 5.02 |
| CHEMBL2425957 | — | — | 1 | 4.74 |
| CHEMBL2425955 | — | — | 1 | 4.74 |
| CHEMBL573 | NIACIN | 4.0 | 1 | 4.36 |
| CHEMBL2425956 | — | — | 1 | - |
| CHEMBL2425954 | — | — | 1 | - |
| CHEMBL2425953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425960 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2425961 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2425959 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL858 | EDETIC ACID | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL2425958 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2425957 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL2425955 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL573 | NIACIN | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL2425956 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2425954 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2425953 | — | IC50 | > | 50000.0 | nM | - |