Assay Detail
Binding
CHEMBL2427727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.59 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425369 | — | — | 2 | 6.97 |
| CHEMBL2425378 | — | — | 2 | 6.47 |
| CHEMBL2425371 | — | — | 2 | 6.02 |
| CHEMBL2425372 | — | — | 2 | 5.77 |
| CHEMBL2425368 | — | — | 2 | 5.76 |
| CHEMBL2425375 | — | — | 2 | 5.58 |
| CHEMBL2425376 | — | — | 2 | 5.46 |
| CHEMBL2425374 | — | — | 2 | 5.44 |
| CHEMBL2425373 | — | — | 2 | 5.38 |
| CHEMBL2425377 | — | — | 2 | 4.49 |
| CHEMBL2425370 | — | — | 2 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425369 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL2425369 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL2425378 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL2425378 | — | Ki | = | 344.0 | nM | 6.46 |
| CHEMBL2425371 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL2425371 | — | Ki | = | 1108.0 | nM | 5.96 |
| CHEMBL2425372 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL2425368 | — | Ki | = | 1737.8 | nM | 5.76 |
| CHEMBL2425368 | — | Ki | = | 1813.0 | nM | 5.74 |
| CHEMBL2425372 | — | Ki | = | 2373.0 | nM | 5.62 |
| CHEMBL2425375 | — | Ki | = | 2630.27 | nM | 5.58 |
| CHEMBL2425375 | — | Ki | = | 2962.0 | nM | 5.53 |
| CHEMBL2425376 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL2425374 | — | Ki | = | 3630.78 | nM | 5.44 |
| CHEMBL2425376 | — | Ki | = | 3775.0 | nM | 5.42 |
| CHEMBL2425374 | — | Ki | = | 3927.0 | nM | 5.41 |
| CHEMBL2425373 | — | Ki | = | 4168.69 | nM | 5.38 |
| CHEMBL2425373 | — | Ki | = | 4314.0 | nM | 5.37 |
| CHEMBL2425377 | — | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL2425377 | — | Ki | = | 32999.0 | nM | 4.48 |
| CHEMBL2425370 | — | Ki | = | 40738.03 | nM | 4.39 |
| CHEMBL2425370 | — | Ki | = | 40607.0 | nM | 4.39 |