Assay Detail
Functional
CHEMBL2428064
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Cytotoxicity against human HL60 cells overexpressing Bcl-XL protein after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity of abietane diterpenoids against human tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425660 | — | — | 1 | 5.96 |
| CHEMBL2204373 | — | — | 1 | 5.66 |
| CHEMBL497082 | TAXODONE | — | 1 | 5.57 |
| CHEMBL2204430 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425660 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2204373 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL497082 | TAXODONE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2204430 | — | IC50 | = | 2900.0 | nM | 5.54 |