Assay Detail
Binding
CHEMBL2428539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL5102) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.79 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425550 | — | — | 1 | 9.24 |
| CHEMBL2425547 | — | — | 1 | 8.93 |
| CHEMBL2425551 | — | — | 1 | 8.89 |
| CHEMBL2425549 | — | — | 1 | 8.79 |
| CHEMBL2425548 | — | — | 1 | 8.79 |
| CHEMBL595262 | — | — | 1 | 8.78 |
| CHEMBL2425546 | — | — | 1 | 8.74 |
| CHEMBL2425544 | — | — | 1 | 8.66 |
| CHEMBL2425545 | — | — | 1 | 8.60 |
| CHEMBL2425543 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425550 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL2425547 | — | Ki | = | 1.17 | nM | 8.93 |
| CHEMBL2425551 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL2425549 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL2425548 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL595262 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL2425546 | — | Ki | = | 1.83 | nM | 8.74 |
| CHEMBL2425544 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL2425545 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2425543 | — | Ki | = | 3.01 | nM | 8.52 |