Assay Detail
Binding
CHEMBL2428641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of urease in Helicobacter pylori ATCC 43504 intact cell assessed as ammonia production preincubated for 1.5 hrs by indophenol-based method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Urease subunit alpha/Urease subunit beta (CHEMBL3885651) ↗| Type | PROTEIN COMPLEX |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.43 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425469 | — | — | 1 | 6.44 |
| CHEMBL2425478 | — | — | 1 | 6.04 |
| CHEMBL2425479 | — | — | 1 | 5.85 |
| CHEMBL2425471 | — | — | 1 | 5.17 |
| CHEMBL2425482 | — | — | 1 | 5.05 |
| CHEMBL2425465 | — | — | 1 | 5.04 |
| CHEMBL2425480 | — | — | 1 | 4.95 |
| CHEMBL2425470 | — | — | 1 | 4.88 |
| CHEMBL2425483 | — | — | 1 | - |
| CHEMBL2425481 | — | — | 1 | - |
| CHEMBL2425477 | — | — | 1 | - |
| CHEMBL2425476 | — | — | 1 | - |
| CHEMBL2425475 | — | — | 1 | - |
| CHEMBL2425474 | — | — | 1 | - |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
| CHEMBL2425472 | — | — | 1 | - |
| CHEMBL2425468 | — | — | 1 | - |
| CHEMBL2425467 | — | — | 1 | - |
| CHEMBL2425466 | — | — | 1 | - |
| CHEMBL2425464 | — | — | 1 | - |
| CHEMBL2425463 | — | — | 1 | - |
| CHEMBL2425473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425469 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2425478 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL2425479 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL2425471 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL2425482 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL2425465 | — | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL2425480 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL2425470 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL2425483 | — | IC50 | - | — | - | |
| CHEMBL2425481 | — | IC50 | - | — | - | |
| CHEMBL2425477 | — | IC50 | - | — | - | |
| CHEMBL2425476 | — | IC50 | - | — | - | |
| CHEMBL2425475 | — | IC50 | - | — | - | |
| CHEMBL2425474 | — | IC50 | - | — | - | |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 110000.0 | nM | - |
| CHEMBL2425472 | — | IC50 | - | — | - | |
| CHEMBL2425468 | — | IC50 | - | — | - | |
| CHEMBL2425467 | — | IC50 | - | — | - | |
| CHEMBL2425466 | — | IC50 | - | — | - | |
| CHEMBL2425464 | — | IC50 | - | — | - | |
| CHEMBL2425463 | — | IC50 | - | — | - | |
| CHEMBL2425473 | — | IC50 | - | — | - |