Assay Detail
Binding
CHEMBL2428686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thrombin inhibitory activity of some polyphenolic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.14 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404515 | CYANIDIN | — | 1 | 8.11 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 7.41 |
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 4.73 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 4.31 |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL2425137 | CYANIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404515 | CYANIDIN | Kd | = | 7.79 | nM | 8.11 |
| CHEMBL50 | QUERCETIN | Kd | = | 38.7 | nM | 7.41 |
| CHEMBL9509 | SILIBININ | Kd | = | 18600.0 | nM | 4.73 |
| CHEMBL311498 | CIANIDANOL | Kd | = | 49200.0 | nM | 4.31 |
| CHEMBL583912 | (-)-EPICATECHIN | Kd | = | 5190000.0 | nM | - |
| CHEMBL2425137 | CYANIN | Kd | = | 8630000.0 | nM | - |