Assay Detail
Binding
CHEMBL2428849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measured every 12 secs for 10 mins by spectrophotometric analysis
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thrombin inhibitory activity of some polyphenolic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 6 | - | - |
| IC50 | 6 | 5.29 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404515 | CYANIDIN | — | 2 | 6.60 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 5.82 |
| CHEMBL9509 | SILIBININ | 3.0 | 2 | 4.60 |
| CHEMBL2425137 | CYANIN | — | 2 | 4.12 |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 2 | - |
| CHEMBL311498 | CIANIDANOL | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404515 | CYANIDIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL9509 | SILIBININ | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2425137 | CYANIN | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL583912 | (-)-EPICATECHIN | Inhibition | - | % | - | |
| CHEMBL311498 | CIANIDANOL | Inhibition | - | % | - | |
| CHEMBL2425137 | CYANIN | Inhibition | - | % | - | |
| CHEMBL9509 | SILIBININ | Inhibition | - | % | - | |
| CHEMBL50 | QUERCETIN | Inhibition | - | % | - | |
| CHEMBL404515 | CYANIDIN | Inhibition | - | % | - | |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | = | 150000.0 | nM | - |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 125000.0 | nM | - |