Assay Detail
Binding
CHEMBL2429072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.18 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426376 | — | — | 1 | 5.46 |
| CHEMBL2426479 | — | — | 1 | 5.33 |
| CHEMBL2426482 | — | — | 1 | 5.13 |
| CHEMBL2426480 | — | — | 1 | 5.10 |
| CHEMBL2426365 | — | — | 1 | 5.06 |
| CHEMBL2426360 | — | — | 1 | 4.97 |
| CHEMBL2426490 | — | — | 1 | - |
| CHEMBL2424677 | — | — | 1 | - |
| CHEMBL2426489 | — | — | 1 | - |
| CHEMBL2426488 | — | — | 1 | - |
| CHEMBL2426487 | — | — | 1 | - |
| CHEMBL2426486 | — | — | 1 | - |
| CHEMBL2426485 | — | — | 1 | - |
| CHEMBL2426484 | — | — | 1 | - |
| CHEMBL2426483 | — | — | 1 | - |
| CHEMBL2426481 | — | — | 1 | - |
| CHEMBL2426498 | — | — | 1 | - |
| CHEMBL2426497 | — | — | 1 | - |
| CHEMBL2426491 | — | — | 1 | - |
| CHEMBL2426492 | — | — | 1 | - |
| CHEMBL2426493 | — | — | 1 | - |
| CHEMBL2426494 | — | — | 1 | - |
| CHEMBL2426495 | — | — | 1 | - |
| CHEMBL2426496 | — | — | 1 | - |
| CHEMBL2426461 | — | — | 1 | - |
| CHEMBL2426465 | — | — | 1 | - |
| CHEMBL2426462 | — | — | 1 | - |
| CHEMBL1235119 | — | — | 1 | - |
| CHEMBL2426463 | — | — | 1 | - |
| CHEMBL2426464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426376 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2426479 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2426482 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2426480 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2426365 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL2426360 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2426364 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426497 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426366 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426367 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426373 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426374 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426375 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2424677 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426362 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426361 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426359 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426466 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426477 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426476 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2424678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426475 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426474 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426463 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1235119 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426462 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426465 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426461 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426496 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426494 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426491 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426489 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426488 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426486 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426485 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426484 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426483 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2426481 | — | IC50 | > | 10000.0 | nM | - |