Compound Detail
CHEMBL2426482
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Basic Information
| ChEMBL ID | CHEMBL2426482 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QVFQGWUDJLAMFR-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
410.6
MW (Da)
3.45
ALogP
4
HBA
0
HBD
30.0
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | IC50 | 6.82 | 6.795 | 150.0 | 2 |
| Lethal(3)malignant brain tumor-like protein 1 CHEMBL1287622 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| TP53-binding protein 1 CHEMBL2424509 | IC50 | 5.13 | 5.13 | 7400.0 | 1 |
| MBT domain-containing protein 1 CHEMBL1287625 | IC50 | 5.09 | 5.09 | 8200.0 | 1 |
| Lethal(3)malignant brain tumor-like protein 4 CHEMBL1287624 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 150.0 | nM | 6.82 | Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins... | 24040942 |
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 170.0 | nM | 6.77 | Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| TP53-binding protein 1 | IC50 | = | 7400.0 | nM | 5.13 | Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| MBT domain-containing protein 1 | IC50 | = | 8200.0 | nM | 5.09 | Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
| Lethal(3)malignant brain tumor-like protein 4 | IC50 | = | 8400.0 | nM | 5.08 | Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay | 24040942 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24040942 | 10.1021/jm400919p | Lethal(3)malignant brain tumor-like protein 3 | 2 |
| 24040942 | 10.1021/jm400919p | Scm-like with four MBT domains protein 1 | 1 |
| 24040942 | 10.1021/jm400919p | Lethal(3)malignant brain tumor-like protein 4 | 1 |
| 24040942 | 10.1021/jm400919p | Lethal(3)malignant brain tumor-like protein 1 | 1 |
| 24040942 | 10.1021/jm400919p | Lysine-specific demethylase 5A | 1 |
| 24040942 | 10.1021/jm400919p | PHD finger protein 23 | 1 |
| 24040942 | 10.1021/jm400919p | E3 ubiquitin-protein ligase UHRF1 | 1 |
| 24040942 | 10.1021/jm400919p | TP53-binding protein 1 | 1 |
| 24040942 | 10.1021/jm400919p | Chromobox protein homolog 7 | 1 |
| 24040942 | 10.1021/jm400919p | MBT domain-containing protein 1 | 1 |
Data from ChEMBL 36 via Core Engine