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Target Snapshot

CHEMBL1287622 Target Snapshot

Lethal(3)malignant brain tumor-like protein 1 · SINGLE PROTEIN · Homo sapiens

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13,926Compounds
28Assays
1Approved Drugs
165.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9Y468. Use UniProt Q9Y468 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y468 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lethal(3)malignant brain tumor-like protein 1 as ChEMBL target CHEMBL1287622, mapped to UniProt Q9Y468. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lethal(3)malignant brain tumor-like protein 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1287622
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y468
Lethal(3)malignant brain tumor-like protein 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lethal(3)malignant brain tumor-like protein 1 is the right protein anchor across sources, using UniProt Q9Y468 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLethal(3)malignant brain tumor-like protein 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9Y468
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLethal(3)malignant brain tumor-like protein 1
UniProt AccessionQ9Y468
Component TypeProtein
Sequence Length840 aa

Lethal(3)malignant brain tumor-like protein 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Lethal(3)malignant brain tumor-like protein 1, mapped to UniProt Q9Y468. Sequence length is 840 aa.

Mapped IDQ9Y468
Review nameLethal(3)malignant brain tumor-like protein 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC50136.0
KD29.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3351077 7.01 IC50 98.0 Clinical
CHEMBL1257003 6.55 IC50 282.0 Preclinical
CHEMBL2426365 6.13 IC50 740.0 Preclinical
CHEMBL2426359 5.92 IC50 1200.0 Preclinical
CHEMBL2426482 5.82 IC50 1500.0 Preclinical
CHEMBL2426366 5.77 IC50 1700.0 Preclinical
CHEMBL2426364 5.7 IC50 2000.0 Preclinical
CHEMBL2426368 5.7 IC50 2000.0 Preclinical
CHEMBL2426480 5.66 IC50 2200.0 Preclinical
CHEMBL2426362 5.64 IC50 2300.0 Preclinical
Distribution

pChEMBL Value Distribution

47
5.0
18
5.5
1
6.0
1
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

28
Total Assays
105
Tested Compounds
2
Assay Types
Binding — 26 assays, 105 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 18 95 5.0
cell-based format 6 10 4.8
assay format 2 0 —
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine