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Assay Detail

CHEMBL2429079

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Binding
Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lethal(3)malignant brain tumor-like protein 3 (CHEMBL1287623) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV.
J Med Chem (2013) 56 : 7358 -7371
PubMed 24040942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 60 6.47 7.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2426365 — — 1 7.41
CHEMBL2426366 — — 1 7.32
CHEMBL2426367 — — 1 7.24
CHEMBL2426364 — — 1 7.19
CHEMBL2426368 — — 1 7.18
CHEMBL2426498 — — 1 7.15
CHEMBL2426360 — — 1 7.14
CHEMBL2426363 — — 1 7.02
CHEMBL2426496 — — 1 7.02
CHEMBL2426481 — — 1 7.00
CHEMBL2424678 — — 1 6.96
CHEMBL2426469 — — 1 6.96
CHEMBL2426476 — — 1 6.92
CHEMBL2426480 — — 1 6.92
CHEMBL2426490 — — 1 6.92
CHEMBL2424677 — — 1 6.89
CHEMBL2426489 — — 1 6.85
CHEMBL2426483 — — 1 6.85
CHEMBL2426495 — — 1 6.80
CHEMBL2426477 — — 1 6.80
CHEMBL2426482 — — 1 6.77
CHEMBL2426376 — — 1 6.77
CHEMBL2426375 — — 1 6.77
CHEMBL2426358 — — 1 6.68
CHEMBL2426359 — — 1 6.68
CHEMBL2426484 — — 1 6.64
CHEMBL2426478 — — 1 6.64
CHEMBL2426374 — — 1 6.62
CHEMBL2426462 — — 1 6.60
CHEMBL2426485 — — 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2426365 — IC50 = 39.0 nM 7.41
CHEMBL2426366 — IC50 = 48.0 nM 7.32
CHEMBL2426367 — IC50 = 58.0 nM 7.24
CHEMBL2426364 — IC50 = 64.0 nM 7.19
CHEMBL2426368 — IC50 = 66.0 nM 7.18
CHEMBL2426498 — IC50 = 71.0 nM 7.15
CHEMBL2426360 — IC50 = 72.0 nM 7.14
CHEMBL2426363 — IC50 = 96.0 nM 7.02
CHEMBL2426496 — IC50 = 96.0 nM 7.02
CHEMBL2426481 — IC50 = 99.0 nM 7.00
CHEMBL2424678 — IC50 = 110.0 nM 6.96
CHEMBL2426469 — IC50 = 110.0 nM 6.96
CHEMBL2426490 — IC50 = 120.0 nM 6.92
CHEMBL2426480 — IC50 = 120.0 nM 6.92
CHEMBL2426476 — IC50 = 120.0 nM 6.92
CHEMBL2424677 — IC50 = 130.0 nM 6.89
CHEMBL2426489 — IC50 = 140.0 nM 6.85
CHEMBL2426483 — IC50 = 140.0 nM 6.85
CHEMBL2426495 — IC50 = 160.0 nM 6.80
CHEMBL2426477 — IC50 = 160.0 nM 6.80
CHEMBL2426482 — IC50 = 170.0 nM 6.77
CHEMBL2426376 — IC50 = 170.0 nM 6.77
CHEMBL2426375 — IC50 = 170.0 nM 6.77
CHEMBL2426358 — IC50 = 210.0 nM 6.68
CHEMBL2426359 — IC50 = 210.0 nM 6.68
CHEMBL2426484 — IC50 = 230.0 nM 6.64
CHEMBL2426478 — IC50 = 230.0 nM 6.64
CHEMBL2426374 — IC50 = 240.0 nM 6.62
CHEMBL2426462 — IC50 = 250.0 nM 6.60
CHEMBL2426485 — IC50 = 270.0 nM 6.57
CHEMBL2426494 — IC50 = 300.0 nM 6.52
CHEMBL2426488 — IC50 = 310.0 nM 6.51
CHEMBL2426461 — IC50 = 330.0 nM 6.48
CHEMBL2426497 — IC50 = 360.0 nM 6.44
CHEMBL2426373 — IC50 = 370.0 nM 6.43
CHEMBL2426471 — IC50 = 400.0 nM 6.40
CHEMBL2426470 — IC50 = 400.0 nM 6.40
CHEMBL2426362 — IC50 = 530.0 nM 6.28
CHEMBL2426466 — IC50 = 560.0 nM 6.25
CHEMBL2426472 — IC50 = 640.0 nM 6.19
CHEMBL2426463 — IC50 = 680.0 nM 6.17
CHEMBL2426361 — IC50 = 690.0 nM 6.16
CHEMBL2426491 — IC50 = 740.0 nM 6.13
CHEMBL2426493 — IC50 = 830.0 nM 6.08
CHEMBL2426479 — IC50 = 1100.0 nM 5.96
CHEMBL2426370 — IC50 = 1200.0 nM 5.92
CHEMBL2426486 — IC50 = 1500.0 nM 5.82
CHEMBL2426473 — IC50 = 1700.0 nM 5.77
CHEMBL2426465 — IC50 = 1800.0 nM 5.75
CHEMBL2426487 — IC50 = 2400.0 nM 5.62