Assay Detail
Functional
CHEMBL2429192
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Cytotoxicity against human MCF7/ADR cells after 72 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.48 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | 2.0 | 1 | 8.00 |
| CHEMBL2425899 | — | — | 1 | 6.29 |
| CHEMBL2425898 | — | — | 1 | 5.14 |
| CHEMBL2425897 | — | — | 1 | - |
| CHEMBL2425896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96172 | EPOTHILONE D | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2425899 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2425898 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2425897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425896 | — | IC50 | - | — | - |