Assay Detail
Binding
CHEMBL2429419
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Inhibition of human DPP8
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.85 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2425069 | — | — | 1 | 6.66 |
| CHEMBL2425078 | — | — | 1 | 4.55 |
| CHEMBL2425067 | — | — | 1 | 4.41 |
| CHEMBL2425076 | — | — | 1 | 4.34 |
| CHEMBL2425074 | — | — | 1 | 4.30 |
| CHEMBL2425081 | — | — | 1 | - |
| CHEMBL2425080 | — | — | 1 | - |
| CHEMBL2425079 | — | — | 1 | - |
| CHEMBL2425077 | — | — | 1 | - |
| CHEMBL2425075 | — | — | 1 | - |
| CHEMBL2425073 | — | — | 1 | - |
| CHEMBL2425072 | — | — | 1 | - |
| CHEMBL2425071 | — | — | 1 | - |
| CHEMBL2425070 | — | — | 1 | - |
| CHEMBL2425082 | — | — | 1 | - |
| CHEMBL2425066 | — | — | 1 | - |
| CHEMBL2425065 | — | — | 1 | - |
| CHEMBL2425064 | — | — | 1 | - |
| CHEMBL2425063 | — | — | 1 | - |
| CHEMBL2425068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2425069 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2425078 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2425067 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL2425076 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL2425074 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2425081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425080 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425075 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425072 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425071 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425082 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425066 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425063 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2425068 | — | IC50 | > | 100000.0 | nM | - |