Compound Detail
CHEMBL2425075
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2425075 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UIVRLOMWONFDGF-WKFLNTIRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
338.3
MW (Da)
2.00
ALogP
4
HBA
2
HBD
67.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human DPP4 | 23972441 |
| Dipeptidyl peptidase 2 | IC50 | = | 38000.0 | nM | 4.42 | Inhibition of QPP (unknown origin) | 23972441 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23972441 | 10.1016/j.bmcl.2013.07.061 | Prolyl endopeptidase FAP | 1 |
| 23972441 | 10.1016/j.bmcl.2013.07.061 | Dipeptidyl peptidase 8 | 1 |
| 23972441 | 10.1016/j.bmcl.2013.07.061 | Dipeptidyl peptidase 2 | 1 |
| 23972441 | 10.1016/j.bmcl.2013.07.061 | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine