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Assay Detail

CHEMBL2429422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of QPP (unknown origin)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dipeptidyl peptidase 2 (CHEMBL3976)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Biftu T, Qian X, Chen P, Feng D, Scapin G, Gao YD, Cox J, Roy RS, Eiermann G, He H, Lyons K, Salituro G, Patel S, Petrov A, Xu F, Xu SS, Zhang B, Caldwell C, Wu JK, Lyons K, Weber AE.
Bioorg Med Chem Lett (2013) 23 : 5361 -5366
PubMed 23972441 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.90 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2425062 1 6.80
CHEMBL2425065 1 5.41
CHEMBL2425076 1 5.18
CHEMBL2425073 1 4.96
CHEMBL2425064 1 4.82
CHEMBL2425081 1 4.81
CHEMBL2425061 1 4.72
CHEMBL2425070 1 4.47
CHEMBL2425075 1 4.42
CHEMBL2425067 1 4.19
CHEMBL2425072 1 4.16
CHEMBL2425080 1 -
CHEMBL2425079 1 -
CHEMBL2425078 1 -
CHEMBL2425077 1 -
CHEMBL2425074 1 -
CHEMBL2425071 1 -
CHEMBL2425069 1 -
CHEMBL2425068 1 -
CHEMBL2425066 1 -
CHEMBL2425063 1 -
CHEMBL2425082 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2425062 IC50 = 160.0 nM 6.80
CHEMBL2425065 IC50 = 3900.0 nM 5.41
CHEMBL2425076 IC50 = 6600.0 nM 5.18
CHEMBL2425073 IC50 = 11000.0 nM 4.96
CHEMBL2425064 IC50 = 15000.0 nM 4.82
CHEMBL2425081 IC50 = 15400.0 nM 4.81
CHEMBL2425061 IC50 = 19000.0 nM 4.72
CHEMBL2425070 IC50 = 34000.0 nM 4.47
CHEMBL2425075 IC50 = 38000.0 nM 4.42
CHEMBL2425067 IC50 = 65000.0 nM 4.19
CHEMBL2425072 IC50 = 70000.0 nM 4.16
CHEMBL2425080 IC50 > 100000.0 nM -
CHEMBL2425079 IC50 > 100000.0 nM -
CHEMBL2425078 IC50 > 100000.0 nM -
CHEMBL2425077 IC50 > 100000.0 nM -
CHEMBL2425074 IC50 > 100000.0 nM -
CHEMBL2425071 IC50 > 100000.0 nM -
CHEMBL2425069 IC50 > 100000.0 nM -
CHEMBL2425068 IC50 > 100000.0 nM -
CHEMBL2425066 IC50 > 100000.0 nM -
CHEMBL2425063 IC50 > 100000.0 nM -
CHEMBL2425082 IC50 > 100000.0 nM -