Assay Detail

CHEMBL2429552

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Functional

Cytotoxicity against human SH-SY5Y cells assessed as cell survival after 48 hrs by trypan blue exclusion assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SH-SY5Y
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Synthetic polyamines activating autophagy: effects on cancer cell death.

Minarini A, Zini M, Milelli A, Tumiatti V, Marchetti C, Nicolini B, Falconi M, Farruggia G, Cappadone C, Stefanelli C.
Eur J Med Chem (2013) 67 : 359 -366
PubMed 23887056 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.05	6.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2398522	—	—	1	6.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2398522	—	IC50	=	900.0	nM	6.05