Assay Detail
Binding
CHEMBL2432395
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.35 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431029 | — | — | 1 | 8.85 |
| CHEMBL2431031 | — | — | 1 | 7.43 |
| CHEMBL2431030 | — | — | 1 | 7.38 |
| CHEMBL2431015 | — | — | 1 | 7.22 |
| CHEMBL2431017 | — | — | 1 | 7.12 |
| CHEMBL2337691 | — | — | 1 | 7.02 |
| CHEMBL2431016 | — | — | 1 | 6.96 |
| CHEMBL2431020 | — | — | 1 | 6.48 |
| CHEMBL2431032 | — | — | 1 | 6.16 |
| CHEMBL94715 | — | — | 1 | 6.05 |
| CHEMBL2431018 | — | — | 1 | 6.04 |
| CHEMBL2431028 | — | — | 1 | 5.79 |
| CHEMBL2431027 | — | — | 1 | 5.36 |
| CHEMBL2431026 | — | — | 1 | 4.96 |
| CHEMBL2431019 | — | — | 1 | 4.54 |
| CHEMBL2431021 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431029 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2431031 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2431030 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2431015 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2431017 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2337691 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2431016 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2431020 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2431032 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL94715 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2431018 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2431028 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL2431027 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2431026 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431019 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2431021 | — | IC50 | = | 51000.0 | nM | 4.29 |