Assay Detail
Binding
CHEMBL2432396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for 20 mins by fluorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 10 (CHEMBL5028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.71 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431028 | — | — | 1 | 6.82 |
| CHEMBL2431027 | — | — | 1 | 6.52 |
| CHEMBL2431026 | — | — | 1 | 5.09 |
| CHEMBL2431021 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2431027 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2431026 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL2431021 | — | IC50 | = | 39000.0 | nM | 4.41 |