Assay Detail
Binding
CHEMBL2433162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length C-terminal His6x-tagged recombinant human HDAC3 expressed in baculovirus using Arg-His-Lys-Lys (Ac) as substrate after 1 hr by fluorescence plate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.85 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431862 | — | — | 1 | 5.35 |
| CHEMBL2431901 | — | — | 1 | 4.34 |
| CHEMBL2431912 | — | — | 1 | - |
| CHEMBL2431907 | — | — | 1 | - |
| CHEMBL2431906 | — | — | 1 | - |
| CHEMBL2431902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431862 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2431901 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2431912 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2431907 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2431906 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2431902 | — | IC50 | > | 50000.0 | nM | - |