Assay Detail
Functional
CHEMBL2433489
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Antiinflammatory activity in mouse macrophages assessed as inhibition of IFN-gamma-induced nitric oxide production after 48 hrs by Griess method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Keap calm, and carry on covalently.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.32 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 9.40 |
| CHEMBL1765578 | — | — | 1 | 6.77 |
| CHEMBL2431568 | — | — | 1 | 5.85 |
| CHEMBL2431569 | — | — | 1 | 5.15 |
| CHEMBL1914935 | — | — | 1 | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1765578 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2431568 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2431569 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1914935 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |