Assay Detail
Functional
CHEMBL2434278
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR green 1 dye-based fluorometric analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.89 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.82 |
| CHEMBL2431496 | — | — | 1 | 7.82 |
| CHEMBL2431499 | — | — | 1 | 7.24 |
| CHEMBL2431515 | — | — | 1 | 7.11 |
| CHEMBL2431513 | — | — | 1 | 6.77 |
| CHEMBL2431488 | — | — | 1 | 6.61 |
| CHEMBL2431514 | — | — | 1 | 6.60 |
| CHEMBL2431504 | — | — | 1 | 6.51 |
| CHEMBL2431497 | — | — | 1 | 6.43 |
| CHEMBL2431498 | — | — | 1 | 6.31 |
| CHEMBL2431500 | — | — | 1 | 6.30 |
| CHEMBL2431502 | — | — | 1 | 6.22 |
| CHEMBL2431501 | — | — | 1 | 6.17 |
| CHEMBL2431517 | — | — | 1 | 6.16 |
| CHEMBL2431480 | — | — | 1 | 6.13 |
| CHEMBL2431489 | — | — | 1 | 6.05 |
| CHEMBL2431503 | — | — | 1 | 6.02 |
| CHEMBL2431522 | — | — | 1 | 5.99 |
| CHEMBL2431518 | — | — | 1 | 5.91 |
| CHEMBL2431516 | — | — | 1 | 5.85 |
| CHEMBL2431505 | — | — | 1 | 5.82 |
| CHEMBL2431521 | — | — | 1 | 5.73 |
| CHEMBL2431519 | — | — | 1 | 5.72 |
| CHEMBL2431510 | — | — | 1 | 5.70 |
| CHEMBL2431523 | — | — | 1 | 5.68 |
| CHEMBL2431506 | — | — | 1 | 5.66 |
| CHEMBL2431485 | — | — | 1 | 5.57 |
| CHEMBL2431484 | — | — | 1 | 5.50 |
| CHEMBL2431487 | — | — | 1 | 5.48 |
| CHEMBL2431492 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2431496 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2431499 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2431515 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2431513 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL2431488 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL2431514 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL2431504 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL2431497 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL2431498 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL2431500 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL2431502 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL2431501 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2431517 | — | IC50 | = | 688.0 | nM | 6.16 |
| CHEMBL2431480 | — | IC50 | = | 745.0 | nM | 6.13 |
| CHEMBL2431489 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2431503 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL2431522 | — | IC50 | = | 1018.0 | nM | 5.99 |
| CHEMBL2431518 | — | IC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL2431516 | — | IC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL2431505 | — | IC50 | = | 1525.0 | nM | 5.82 |
| CHEMBL2431521 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL2431519 | — | IC50 | = | 1907.0 | nM | 5.72 |
| CHEMBL2431510 | — | IC50 | = | 1992.0 | nM | 5.70 |
| CHEMBL2431523 | — | IC50 | = | 2107.0 | nM | 5.68 |
| CHEMBL2431506 | — | IC50 | = | 2191.0 | nM | 5.66 |
| CHEMBL2431485 | — | IC50 | = | 2696.0 | nM | 5.57 |
| CHEMBL2431484 | — | IC50 | = | 3173.0 | nM | 5.50 |
| CHEMBL2431487 | — | IC50 | = | 3342.0 | nM | 5.48 |
| CHEMBL2431492 | — | IC50 | = | 3476.0 | nM | 5.46 |
| CHEMBL2431481 | — | IC50 | = | 3534.0 | nM | 5.45 |
| CHEMBL2431509 | — | IC50 | = | 4031.0 | nM | 5.39 |
| CHEMBL2431511 | — | IC50 | = | 5048.0 | nM | 5.30 |
| CHEMBL2431507 | — | IC50 | = | 5614.0 | nM | 5.25 |
| CHEMBL2431493 | — | IC50 | = | 5831.0 | nM | 5.23 |
| CHEMBL1334527 | — | IC50 | = | 5903.0 | nM | 5.23 |
| CHEMBL2431486 | — | IC50 | = | 6618.0 | nM | 5.18 |
| CHEMBL2431490 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL2431483 | — | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL2431494 | — | IC50 | = | 10233.0 | nM | 4.99 |
| CHEMBL2431491 | — | IC50 | = | 11148.0 | nM | 4.95 |
| CHEMBL2431495 | — | IC50 | = | 12402.0 | nM | 4.91 |
| CHEMBL2431508 | — | IC50 | = | 14351.0 | nM | 4.84 |
| CHEMBL2431482 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2431512 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2431520 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1732938 | — | IC50 | > | 20000.0 | nM | - |