Assay Detail
Binding
CHEMBL2434417
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Binding affinity at human 5HT1A receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.54 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.47 |
| CHEMBL2089156 | — | — | 1 | 8.24 |
| CHEMBL1276220 | — | — | 1 | 8.22 |
| CHEMBL1276218 | — | — | 1 | 8.14 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 7.98 |
| CHEMBL2431282 | — | — | 1 | 7.86 |
| CHEMBL1956197 | — | — | 1 | 7.83 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 7.55 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.46 |
| CHEMBL1276140 | — | — | 1 | 7.45 |
| CHEMBL2089155 | — | — | 1 | 7.40 |
| CHEMBL14107 | — | — | 1 | 7.15 |
| CHEMBL2431280 | — | — | 1 | 7.10 |
| CHEMBL13917 | — | — | 1 | 7.10 |
| CHEMBL2431281 | — | — | 1 | 7.08 |
| CHEMBL1956192 | — | — | 1 | 6.83 |
| CHEMBL2431279 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 3.388 | nM | 8.47 |
| CHEMBL2089156 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL1276220 | — | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL1276218 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL1956195 | CYCLOMETHYLINE | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL2431282 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL1956197 | — | Ki | = | 14.79 | nM | 7.83 |
| CHEMBL495095 | ALLYPHENYLINE | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL13852 | CIRAZOLINE | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL1276140 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL2089155 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL14107 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL2431280 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL13917 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL2431281 | — | Ki | = | 83.18 | nM | 7.08 |
| CHEMBL1956192 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL2431279 | — | Ki | = | 562.34 | nM | 6.25 |