Assay Detail
Binding
CHEMBL2434541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFR-beta (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.46 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2430265 | — | — | 1 | 8.12 |
| CHEMBL2180602 | TAFETINIB | 1.0 | 1 | 8.00 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.97 |
| CHEMBL2430264 | — | — | 1 | 7.92 |
| CHEMBL2430262 | — | — | 1 | 7.90 |
| CHEMBL2430254 | — | — | 1 | 7.88 |
| CHEMBL2430258 | — | — | 1 | 7.88 |
| CHEMBL2430266 | — | — | 1 | 7.81 |
| CHEMBL2430248 | — | — | 1 | 7.75 |
| CHEMBL2430259 | — | — | 1 | 7.71 |
| CHEMBL2430250 | — | — | 1 | 7.71 |
| CHEMBL2430247 | — | — | 1 | 7.67 |
| CHEMBL2430261 | — | — | 1 | 7.64 |
| CHEMBL2430251 | — | — | 1 | 7.40 |
| CHEMBL2430252 | — | — | 1 | 7.39 |
| CHEMBL2430260 | — | — | 1 | 7.38 |
| CHEMBL2430256 | — | — | 1 | 7.21 |
| CHEMBL2430249 | — | — | 1 | 7.19 |
| CHEMBL2430255 | — | — | 1 | 7.15 |
| CHEMBL2430263 | — | — | 1 | 7.05 |
| CHEMBL2430267 | — | — | 1 | 6.99 |
| CHEMBL2430253 | — | — | 1 | 6.93 |
| CHEMBL2430198 | — | — | 1 | 6.79 |
| CHEMBL2430257 | — | — | 1 | 6.58 |
| CHEMBL2429872 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2430265 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2180602 | TAFETINIB | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL535 | SUNITINIB | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL2430264 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL2430262 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL2430254 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL2430258 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL2430266 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL2430248 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2430259 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL2430250 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL2430247 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL2430261 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL2430251 | — | IC50 | = | 40.1 | nM | 7.40 |
| CHEMBL2430252 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL2430260 | — | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL2430256 | — | IC50 | = | 62.1 | nM | 7.21 |
| CHEMBL2430249 | — | IC50 | = | 64.8 | nM | 7.19 |
| CHEMBL2430255 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL2430263 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL2430267 | — | IC50 | = | 101.4 | nM | 6.99 |
| CHEMBL2430253 | — | IC50 | = | 118.4 | nM | 6.93 |
| CHEMBL2430198 | — | IC50 | = | 160.6 | nM | 6.79 |
| CHEMBL2430257 | — | IC50 | = | 260.3 | nM | 6.58 |
| CHEMBL2429872 | — | IC50 | = | 395.7 | nM | 6.40 |