Assay Detail
Binding
CHEMBL2434578
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Agonist activity at human alpha2C AR
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.24 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2089156 | — | — | 1 | 8.70 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 8.70 |
| CHEMBL1956192 | — | — | 1 | 8.00 |
| CHEMBL1276140 | — | — | 1 | 7.60 |
| CHEMBL2431282 | — | — | 1 | 7.60 |
| CHEMBL1276220 | — | — | 1 | 7.45 |
| CHEMBL1276218 | — | — | 1 | 7.40 |
| CHEMBL1956197 | — | — | 1 | 7.32 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 7.30 |
| CHEMBL14107 | — | — | 1 | 7.21 |
| CHEMBL2431279 | — | — | 1 | 7.01 |
| CHEMBL1276219 | — | — | 1 | 6.90 |
| CHEMBL13917 | — | — | 1 | 6.81 |
| CHEMBL1276139 | — | — | 1 | 6.73 |
| CHEMBL2431281 | — | — | 1 | 6.63 |
| CHEMBL2089155 | — | — | 1 | 6.50 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 6.40 |
| CHEMBL2431280 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2089156 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1956195 | CYCLOMETHYLINE | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1956192 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1276140 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL2431282 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1276220 | — | EC50 | = | 35.48 | nM | 7.45 |
| CHEMBL1276218 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1956197 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL495095 | ALLYPHENYLINE | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL14107 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL2431279 | — | EC50 | = | 97.72 | nM | 7.01 |
| CHEMBL1276219 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL13917 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL1276139 | — | EC50 | = | 186.21 | nM | 6.73 |
| CHEMBL2431281 | — | EC50 | = | 234.42 | nM | 6.63 |
| CHEMBL2089155 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2431280 | — | EC50 | = | 1000.0 | nM | 6.00 |