Assay Detail
Functional
CHEMBL2434701
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Cytotoxicity against human MDA468 cells assessed as cell viability after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.96 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431935 | — | — | 1 | 5.30 |
| CHEMBL2431952 | — | — | 1 | 5.17 |
| CHEMBL2431955 | — | — | 1 | 5.09 |
| CHEMBL2431957 | — | — | 1 | 5.07 |
| CHEMBL2431993 | — | — | 1 | 4.96 |
| CHEMBL1829876 | — | — | 1 | 4.96 |
| CHEMBL2431995 | — | — | 1 | 4.89 |
| CHEMBL2431956 | — | — | 1 | 4.87 |
| CHEMBL2431994 | — | — | 1 | 4.85 |
| CHEMBL2431941 | — | — | 1 | 4.77 |
| CHEMBL2431990 | — | — | 1 | 4.77 |
| CHEMBL1829786 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431935 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2431952 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2431955 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2431957 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2431993 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1829876 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431995 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2431956 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL2431994 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2431941 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2431990 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1829786 | — | IC50 | = | 17000.0 | nM | 4.77 |