Assay Detail
Binding
CHEMBL2434703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive binding affinity to Stat3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after 30 mins by fluorescence polarization assay
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 4.86 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431993 | — | — | 1 | 5.55 |
| CHEMBL2431942 | — | — | 1 | 5.30 |
| CHEMBL2431970 | — | — | 1 | 5.30 |
| CHEMBL2431991 | — | — | 1 | 5.28 |
| CHEMBL2431964 | — | — | 1 | 5.22 |
| CHEMBL2431965 | — | — | 1 | 5.21 |
| CHEMBL2431966 | — | — | 1 | 5.14 |
| CHEMBL2431945 | — | — | 1 | 5.12 |
| CHEMBL2431962 | — | — | 1 | 5.12 |
| CHEMBL2431967 | — | — | 1 | 5.10 |
| CHEMBL2431941 | — | — | 1 | 5.09 |
| CHEMBL2431980 | — | — | 1 | 5.07 |
| CHEMBL2431990 | — | — | 1 | 5.06 |
| CHEMBL2431961 | — | — | 1 | 5.05 |
| CHEMBL2431995 | — | — | 1 | 5.04 |
| CHEMBL2431931 | — | — | 1 | 5.03 |
| CHEMBL2431956 | — | — | 1 | 5.02 |
| CHEMBL2431944 | — | — | 1 | 5.02 |
| CHEMBL2431969 | — | — | 1 | 5.00 |
| CHEMBL2431926 | — | — | 1 | 4.99 |
| CHEMBL2431994 | — | — | 1 | 4.99 |
| CHEMBL2431960 | — | — | 1 | 4.97 |
| CHEMBL2431923 | — | — | 1 | 4.96 |
| CHEMBL2431971 | — | — | 1 | 4.96 |
| CHEMBL2431943 | — | — | 1 | 4.96 |
| CHEMBL2431935 | — | — | 1 | 4.96 |
| CHEMBL2431929 | — | — | 1 | 4.94 |
| CHEMBL2431947 | — | — | 1 | 4.94 |
| CHEMBL2431968 | — | — | 1 | 4.93 |
| CHEMBL2431952 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431993 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2431942 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2431970 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2431991 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2431964 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2431965 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2431966 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2431945 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2431962 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2431967 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2431941 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2431980 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2431990 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2431961 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2431995 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2431931 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2431956 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL2431944 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL2431969 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2431926 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2431994 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2431960 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL2431935 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431943 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431923 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431971 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2431929 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL2431947 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL2431968 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2431952 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2431932 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL2431979 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL2431973 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL2431955 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL2431925 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL2431953 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2431989 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2431951 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2431954 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2431939 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL2431963 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2023989 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2431934 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL2431986 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2431937 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL2431933 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL2431927 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2431922 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL2431959 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL2431985 | — | IC50 | = | 17800.0 | nM | 4.75 |