Assay Detail
Binding
CHEMBL2434704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Stat3 (unknown origin) using hSIE as probe preincubated for 30 mins followed by hSIE addition by electrophoretic mobility shift assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.41 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829876 | — | — | 1 | 5.17 |
| CHEMBL2172013 | — | — | 1 | 4.37 |
| CHEMBL477936 | — | — | 1 | 4.08 |
| CHEMBL2431984 | — | — | 1 | 4.02 |
| CHEMBL2023989 | — | — | 1 | - |
| CHEMBL2431983 | — | — | 1 | - |
| CHEMBL2431982 | — | — | 1 | - |
| CHEMBL2431981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829876 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2172013 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL477936 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL2431984 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL2023989 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL2431983 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2431982 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2431981 | — | IC50 | > | 300000.0 | nM | - |