Assay Detail
Binding
CHEMBL2434719
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Inhibition of Staphylococcus aureus TrmD using S-[methyl-3H] adenosyl-L-methionine as substrate assessed as leucine-tRNA methylation after 1 hr by scintillation proximity assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.06 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431997 | — | — | 1 | 5.92 |
| CHEMBL2432026 | — | — | 1 | 5.85 |
| CHEMBL2432013 | — | — | 1 | 5.75 |
| CHEMBL2432009 | — | — | 1 | 5.75 |
| CHEMBL2432027 | — | — | 1 | 5.64 |
| CHEMBL2432016 | — | — | 1 | 5.57 |
| CHEMBL2432021 | — | — | 1 | 5.57 |
| CHEMBL2432012 | — | — | 1 | 5.54 |
| CHEMBL2432000 | — | — | 1 | 5.37 |
| CHEMBL2432015 | — | — | 1 | 5.36 |
| CHEMBL2432014 | — | — | 1 | 5.33 |
| CHEMBL2432022 | — | — | 1 | 5.28 |
| CHEMBL2432006 | — | — | 1 | 5.26 |
| CHEMBL2432017 | — | — | 1 | 5.20 |
| CHEMBL2432007 | — | — | 1 | 5.18 |
| CHEMBL2432023 | — | — | 1 | 5.17 |
| CHEMBL2431996 | — | — | 1 | 5.14 |
| CHEMBL2432010 | — | — | 1 | 5.13 |
| CHEMBL2432018 | — | — | 1 | 5.12 |
| CHEMBL2432011 | — | — | 1 | 5.09 |
| CHEMBL1369722 | — | — | 1 | 4.96 |
| CHEMBL2432002 | — | — | 1 | 4.92 |
| CHEMBL2432008 | — | — | 1 | 4.92 |
| CHEMBL2432020 | — | — | 1 | 4.85 |
| CHEMBL2432030 | — | — | 1 | 4.68 |
| CHEMBL2432019 | — | — | 1 | 4.66 |
| CHEMBL2432005 | — | — | 1 | 4.60 |
| CHEMBL2432001 | — | — | 1 | 4.57 |
| CHEMBL2432029 | — | — | 1 | 4.47 |
| CHEMBL2432003 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431997 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2432026 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2432009 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2432013 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2432027 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2432016 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2432021 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2432012 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2432000 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2432015 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2432014 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2432022 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2432006 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2432017 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2432007 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2432023 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2431996 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2432010 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2432018 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2432011 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1369722 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2432008 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2432002 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2432020 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2432030 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2432019 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2432005 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2432001 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2432029 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2432003 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1427554 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2432033 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL2432035 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL2432036 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1214186 | SINEFUNGIN | IC50 | = | 160000.0 | nM | - |
| CHEMBL2432025 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2432028 | — | IC50 | = | 1336000.0 | nM | - |
| CHEMBL2432031 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2432032 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2432034 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2432037 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2431998 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2431999 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2432004 | — | IC50 | = | 105000.0 | nM | - |